...so really, if you like to rely more on your keyboard than your mouse and already use apps like Quicksilver, Launchbar, Alfred or SizeUp etc. you will probably love The Hit List...
It's been about 2 years now since I first heard of GTD and started applying some of it's principles to my own todo's. I can't say I do a 100% GTD but let's say it inspired me. For most of the time in those 2 years I used Things by Cultured Code to manage my todos on my Mac's and later, to some extent, on the iPhone (more about that further down the post). Things looks quite nice. It has a very clutter free UI that has worked pretty well for me so far:

However, syncronisation is an issue. I can sync between the 3 Mac's I use regularly by keeping the Things' Database.xml on my dropbox. Occasionally I forget to close Things on one Mac and then dropbox' restore functionality saves the day, so it's not really a smooth and painless way of syncing. It gets even more painful when you add an iPhone to the mix. The Cultured Code team has been promising cloud sync functionality for quite a while now (I believe it's been more than a year now) and there's still no beta, demo or official statement other than the "FULL SPEED" on their status board. I know there's some people quite frustrated about that lack of updates about that feature ;-)
This post is not a rant about Things or Cultured Code though. A few days before my holidays, my todo lists started piling up, as it was a busy period at work and I had quite a lot of other things to deal with in the bureaucratic department. During my holidays I never even looked at my todos (thankfully!) but after I got back things didn't get much better obviously. So I fired up Things recently and was a bit overwhelmed by the quantity of items on my lists. Many of the todo's were already obsoleted or needed an update, and I wanted to reorganize and clean up some lists.
Somehow I realized that Things was not so very handy at managing a lot of todos and keeping them organized the way I wanted them. Or I just needed to procrastinate a little bit. So I went googling for some alternatives, with the syncing issues described above in mind as well. Unfortunately I didn't find any new GTD app for the Mac that would do cloud syncing, and I had already looked at OmniFocus, which I turned down because I just couldn't live with it's UI (yes, I care a great deal about aesthetics of a user interface and how it feels). But I stumbled about this blog post in which the author explains why he thinks Things is not a real GTD app. Though I don't really agree the post was quite interesting and in the comments several people mentioned an OSX app called The Hit List. I looked it up and downloaded the Beta since it looked interesting enough.

It is still in beta, and does not offer any cloud syncing yet, so don't get your hopes up to high. But I definitely recommend you give it a try if you're currently using Things or OmniFocus. It might be just right for you, as it was for me. The UI looks a little bit more cluttered than Things but is still quite minimalistic as you can see in the screenshot. You can organize and manage your todo's in lots of different ways according to your preference and workflow, which I found quite awesome. The Hit List is generally speaking a bit less minimalistic (UI and feature wise) than Things and therefore quite a bit more flexible in the ways you can use it but it is still focused enough so you don't get lost in it's menu's.
And the little dark bar you can see at the bottom of the screenshot is the most amazing thing about The Hit List and the reason why I've been using it instead of Things ever since I installed it: It displays hints for the keyboard shortcuts currently available to you which is quite handy. Pretty much everything I want to do in the app I can do by using my keyboard, so really, if you like to rely more on your keyboard than your mouse and already use apps like Quicksilver, Launchbar, Alfred or SizeUp etc. you will probably love The Hit List. And thanks to the hints bar, the learning curve is very shallow.
In the end, my biggest issue with Things has not been solved by The Hit List either. You could even say it is a step back since there is no iPhone app available just yet. But the ability to keep my todo's organized exactly how I want them and the awesome keyboard interface made me switch without hesitation. I like the way The Hit List handles keyboard input so much that I wish I could have a ruby IDE that does the same.
By the way, if you open Things and The Hit List side by side, you can select your todo's in Things and drag them over to The Hit List all at once.